Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.10 extracted from

  • Lebowitz, J.; Edinger, R.S.; An, B.; Perry, C.J.; Onate, S.; Kleyman, T.R.; Johnson, J.P.
    IkappaB kinase-beta (IKKbeta) modulation of epithelial sodium channel activity (2004), J. Biol. Chem., 279, 41985-41990.
    View publication on PubMed
Search for more literature for 2.7.11.10

Activating Compound

Activating Compound Comment Organism Structure
additional information aldosterone regulates IKKbeta activity by enzyme induction Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
expression of IKKbeta in the yeast two-hybrid system, interaction with epithelial sodium channel alphabetagamma-ENaC, coexpression of IKKbeta and alphabeta-FLAG-gamma-ENaC in Xenopus laevis oocytes increases amilorid-sensitive current Mus musculus

Protein Variants

Protein Variants Comment Organism
K44A inactive IKKbeta mutant Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus IKKbeta is required for activation of NFkappaB, IKKbeta induces expression of epithelial sodium channel alphabetagamma-ENaC in cell surfaces ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epithelium
-
 Mus musculus
-
mpkCCDc14 cell immortal mpkCCDc14 cell line, derived from transgenic mice Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information IKKbeta is required for activation of NFkappaB, IKKbeta induces expression of epithelial sodium channel alphabetagamma-ENaC in cell surfaces Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
IKKbeta
-
 Mus musculus