Any feedback?
Literature summary for 2.7.11.10 extracted from
- A role for NF-kappaB essential modifier/IkappaB kinase-gamma (NEMO/IKKgamma) ubiquitination in the activation of the IkappaB kinase complex by tumor necrosis factor-alpha (2003), J. Biol. Chem., 278, 37297-37305.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | IKK is induced by TNFalpha | Homo sapiens | |
| NEMO | i.e. NF-kappaB essential modifier, complexing with IkappaB kinase-gamma and ubiquination, involving the zinc finger of NEMO and c-IAP1, are required for activation of the IkappaB kinase complex by inflammatory stimuli such as tumor necrosis factor TNFalpha | Homo sapiens |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + [GST-IkappaB protein] | Homo sapiens | - |
ADP + [GST-IkappaB phosphoprotein] | - |
? | |
| additional information | Homo sapiens | defective ubiquination of the NF-kappaB essential modifier/IkappaB kinase-gamma complex leads to impaired cellular NFkappaB signalling and hypohidrotic ectodermal dysplasia with immunodeficiency HED-ID | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HEK-293T cell | - |
Homo sapiens | - |
| HeLa cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + [GST-IkappaB protein] | - |
Homo sapiens | ADP + [GST-IkappaB phosphoprotein] | - |
? | |
| additional information | defective ubiquination of the NF-kappaB essential modifier/IkappaB kinase-gamma complex leads to impaired cellular NFkappaB signalling and hypohidrotic ectodermal dysplasia with immunodeficiency HED-ID | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| IkappaB kinase complex | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
