Literature summary for 2.7.10.2 extracted from

Dasari, T.; Geiger, R.; Karki, R.; Banoth, B.; Sharma, B.; Gurung, P.; Burton, A.; Kanneganti, T.
The nonreceptor tyrosine kinase SYK drives caspase-8/NLRP3 inflammasome-mediated autoinflammatory osteomyelitis (2020), J. Biol. Chem., 295, 3394-3400 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P43405	-	-
Mus musculus	P48025	-	-

Synonyms

Synonyms	Comment	Organism
nonreceptor tyrosine kinase SYK	-	Homo sapiens
nonreceptor tyrosine kinase SYK	-	Mus musculus

General Information

General Information	Comment	Organism
drug target	SYK and its downstream signaling components represent promising novel therapeutic targets in chronic recurrent multifocal osteomyelitis (CRMO)	Homo sapiens
physiological function	the enzyme (SYK) drives caspase-8/NLRP3 inflammasome-mediated autoinflammatory osteomyelitis. SYK centrally mediates signaling upstream of caspase-1 and caspase-8 activation and principally up-regulates NF-kappaB and IL-1beta signaling in Pstpip2(cmo) mice, thereby inducing cmo	Mus musculus
physiological function	the enzyme (SYK) drives caspase-8/NLRP3 inflammasome-mediated autoinflammatory osteomyelitis. SYK critically up-regulates the pro-IL-1x02production responsible for cmo disease progression and proinflammatory NF-kappaB signaling, which contributes to pro-IL-1x02 up-regulation	Homo sapiens

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Release 2023.1 (January 2023)