Literature summary for 2.7.10.2 extracted from

Badger, J.; Grover, P.; Shi, H.; Panjarian, S.B.; Engen, J.R.; Smithgall, T.E.; Makowski, L.
c-Abl tyrosine kinase adopts multiple active conformational states in solution (2016), Biochemistry, 55, 3251-3260.

Search for more literature for 2.7.10.2

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Sf9 insect cells	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
A356N	the mutation increases enzyme activity	Homo sapiens
T315I	the mutation increases enzyme activity	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
imatinib	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P00519	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + a [Tyr-2 peptide]-L-tyrosine	-	Homo sapiens	ADP + a [Tyr-2 peptide]-L-tyrosine phosphate	-	?

Synonyms

Synonyms	Comment	Organism
c-Abl tyrosine kinase	-	Homo sapiens

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Release 2023.1 (January 2023)