Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.10.2 extracted from

  • Ko, H.S.; Lee, Y.; Shin, J.H.; Karuppagounder, S.S.; Gadad, B.S.; Koleske, A.J.; Pletnikova, O.; Troncoso, J.C.; Dawson, V.L.; Dawson, T.M.
    Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function (2010), Proc. Natl. Acad. Sci. USA, 107, 16691-16696.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine nonreceptor tyrosine kinase c-Abl phosphorylates tyrosine 143 of parkin, which encodes a ubiquitin E3 ligase, related to autosomal recessive Parkinson disease. Phosphorylation inhibits parkin’s ubiquitin E3 ligase activity and protective function. Tyrosine phosphorylation of parkin by c-Abl is a major posttranslational modification that inhibits parkin function, possibly contributing to pathogenesis of sporadic Parkinson's disease Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
-
Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
imatinib a c-Abl-family kinase inhibitor, prevents the phosphorylation of substrate parkin, maintaining parkin in a catalytically active and protective state. The protective effects require parkin Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [parkin]-Tyr143 Homo sapiens
-
ADP + [parkin]-phospho-Tyr143 nonreceptor tyrosine kinase c-Abl phosphorylates tyrosine 143 of parkin, which encodes a ubiquitin E3 ligase, related to autosomal recessive Parkinson disease. Phosphorylation inhibits parkin's ubiquitin E3 ligase activity and protective function ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain in human postmortem Parkinson's disease brain, isoform c-Abl is active, substrate parkin is tyrosine-phosphorylated, and parkin substrates aminoacyl-tRNA synthetase-interacting multifunctional protein type 2, AIMP2, and fuse-binding protein 1, FBP1, accumulate in the substantia nigra and striatum Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [parkin]-Tyr143
-
Homo sapiens ADP + [parkin]-phospho-Tyr143 nonreceptor tyrosine kinase c-Abl phosphorylates tyrosine 143 of parkin, which encodes a ubiquitin E3 ligase, related to autosomal recessive Parkinson disease. Phosphorylation inhibits parkin's ubiquitin E3 ligase activity and protective function ?

Synonyms

Synonyms Comment Organism
c-ABL
-
Homo sapiens

General Information

General Information Comment Organism
physiological function conditional knockout of isoform c-Abl in the nervous system prevents the phosphorylation of substrate parkin, the accumulation of parkin substrates aminoacyl-tRNA synthetase-interacting multifunctional protein type 2, AIMP2, and fuse-binding protein 1, FBP, and subsequent neurotoxicity in response to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine intoxication Homo sapiens