Literature summary for 2.7.10.2 extracted from

Ma, Y.C.; Shi, C.; Zhang, Y.N.; Wang, L.G.; Liu, H.; Jia, H.T.; Zhang, Y.X.; Sarkar, F.H.; Wang, Z.S.
The tyrosine kinase c-Src directly mediates growth factor-induced Notch-1 and Furin interaction and Notch-1 activation in pancreatic cancer cells (2012), PLoS ONE, 7, e33414.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
pancreas	-	Homo sapiens	-
pancreatic cancer cell	isoform c-Src and Notch-1 co-localize in tissues of pancreatic cancer patients	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
C-SRC	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	Notch-1-Furin interaction is regulated by the non-receptor tyrosine kinase, c-Src. c-Src and Notch-1 are physically associated, and this association is responsible for Notch-1 processing and activation. Growth factor TGF-alpha, an epidermal growth factor receptor ligand, and PDGF-BB, a platelet derived growth factor receptor ligand, induce the Notch-1-Furin interaction mediated by c-Src. The association between Notch-1 and Furin is a well-regulated process, extracellular growth factor signals regulate this interaction, which is mediated by c-Src, and there is cross-talk between the plasma growth factor receptor-c-Src and Notch pathways	Homo sapiens

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Release 2023.1 (January 2023)