Application | Comment | Organism |
---|---|---|
analysis | the fluorescence properties of bosutinib and related compounds allow inhibitor binding to be measured quantitatively, and the infrared absorption of the nitrile group reveals a different electrostatic environment in the conserved ATP-binding sites of Abl and Src kinases | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
inhibitor bosutinib bound to the kinase domain of isoform Abl, to 2.4 A resolution. Two distinct chemical compounds are currently being sold under the name bosutinib, spectroscopic and structural characterizations of both Structure reveals that similar inhibitors that lack a nitrile moiety could be effective against the common T315I mutant | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
bosutinib | two distinct chemical compounds are currently being sold under the name bosutinib, spectroscopic and structural characterizations of both | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P00519 | ABL1 | - |
Synonyms | Comment | Organism |
---|---|---|
Abl | - |
Homo sapiens |