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Literature summary for 2.7.10.2 extracted from

  • Kim, N.H.; Park, K.S.; Cha, S.K.; Yoon, J.H.; Yeh, B.I.; Han, K.H.; Kong, I.D.
    Src family kinase potentiates the activity of nicotinic acetylcholine receptor in rat autonomic ganglion innervating urinary bladder (2011), Neurosci. Lett., 494, 190-195.
    View publication on PubMed
Search for more literature for 2.7.10.2

Inhibitors

Inhibitors Comment Organism Structure
4-amino-5-(4-chlorophenyl)-7-(tert-butyl)pyrazolo[3,4-d]pyrimidine selective Src-kinase inhibitors 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo[3,4-d]pyrimidine and 4-amino-5-(4-chlorophenyl)-7-(tert-butyl)pyrazolo[3,4-d]pyrimidine, at 5 microM, attenuate acetylcholine-induced ionic currents and intracellular Ca2+ ion concentration transients in major pelvic ganglion neurons Rattus norvegicus
4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo[3,4-d]pyrimidine selective Src-kinase inhibitors 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo[3,4-d]pyrimidine and 4-amino-5-(4-chlorophenyl)-7-(tert-butyl)pyrazolo[3,4-d]pyrimidine, at 5 microM, attenuate acetylcholine-induced ionic currents and intracellular Ca2+ ion concentration transients in major pelvic ganglion neurons Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
neuron major pelvic ganglion neuron Rattus norvegicus
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urinary bladder autonomic ganglion innervating urinary bladder Rattus norvegicus
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General Information

General Information Comment Organism
physiological function selective Src-kinase inhibitors 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo[3,4-d]pyrimidine and 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine, at 5 microM, attenuate acetylcholine-induced ionic currents and intracellular Ca2+ ion concentration transients in major pelvic ganglion neurons. Blocking the tyrosine kinase activity of Src kinase by pp60 c-src inhibitory peptide also reduces the acetylcholine-induced currents. Sodium orthovanadate, at 200 microM, a tyrosine phosphatase inhibitor, significantly augments the acetylcholine-induced currents Rattus norvegicus