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Literature summary for 2.7.10.2 extracted from

  • Fei, F.; Kweon, S.; Haataja, L.; De Sepulveda, P.; Groffen, J.; Heisterkamp, N.
    The Fer tyrosine kinase regulates interactions of Rho GDP-dissociation inhibitor alpha with the small GTPase Rac (2010), BMC Biochem., 11, 48.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.10.2

Activating Compound

Activating Compound Comment Organism Structure
pervanadate activation of isoform Fer by reactive oxygen species causes increased phosphorylation of RhoGDIalpha, regulator of the small GTPase Rac, and pervanadate treatment further augmented this Homo sapiens
reactive oxygen species activation of isoform Fer by reactive oxygen species causes increased phosphorylation of RhoGDIalpha, regulator of the small GTPase Rac, and pervanadate treatment further augmented this Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P16591 FER
-

Synonyms

Synonyms Comment Organism
FER tyrosine kinase
-
 Homo sapiens
TYK3
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function non-receptor tyrosine kinase Fer is able to phosphorylate RhoGDIalpha, regulator of the small GTPase Rac, and form a direct protein complex with it. This interaction is mediated by the C-terminal end of RhoGDIalpha. Tyrosine phosphorylation of RhoGDIalpha by Fer prevents subsequent binding of Rac to RhoGDIalpha, but once a RhoGDIalpha-Rac complex is formed, the Fer kinase is not able to cause Rac release through tyrosine phosphorylation of preformed RhoGDIalpha-Rac complexes Homo sapiens