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Literature summary for 2.7.10.2 extracted from

  • Wang, Y.; Fiskus, W.; Chong, D.G.; Buckley, K.M.; Natarajan, K.; Rao, R.; Joshi, A.; Balusu, R.; Koul, S.; Chen, J.; Savoie, A.; Ustun, C.; Jillella, A.P.; Atadja, P.; Levine, R.L.; Bhalla, K.N.
    Cotreatment with panobinostat and JAK2 inhibitor TG101209 attenuates JAK2V617F levels and signaling and exerts synergistic cytotoxic effects against human myeloproliferative neoplastic cells (2009), Blood, 114, 5024-5033.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
the mutant V617F is expressed in Ba/F3 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
V617F the mutant activates downstream signaling through the signal transducers and activators of transcription, RAS/mitogen-activated protein kinase, and phosphatidylinositol 3 /AKT pathways, conferring proliferative and survival advantages in the myeloproliferative neoplasm hematopoietic progenitor cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
TG101209 Jak2 inhibitor Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O60674
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEL92.1.7 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
JAK2
-
 Homo sapiens
Janus kinase 2
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens