Protein Variants | Comment | Organism |
---|---|---|
V617F | the mutation is responsible for the majority of breakpoint cluster region/Abelson -negative myeloproliferative disorders | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
AZ960 | potent and selective ATP competitive inhibitor of JAK2 enzyme activity | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a [protein]-L-tyrosine | Homo sapiens | - |
ADP + a [protein]-L-tyrosine phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O60674 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293T cell | - |
Homo sapiens | - |
HEL cell | - |
Homo sapiens | - |
K-562 cell | - |
Homo sapiens | - |
PBMC cell | CD34+ | Homo sapiens | - |
SET-2 cell | - |
Homo sapiens | - |
UKE-1 cell | - |
Homo sapiens | - |
UT-7 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a [protein]-L-tyrosine | - |
Homo sapiens | ADP + a [protein]-L-tyrosine phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
JAK2 | - |
Homo sapiens |
Janus kinase 2 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |