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Literature summary for 2.7.10.2 extracted from

  • Sandilands, E.; Frame, M.C.
    Endosomal trafficking of Src tyrosine kinase (2008), Trends Cell Biol., 18, 322-329.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information autophosphorylation of Y416 leads to the activation of c-Src Homo sapiens

Application

Application Comment Organism
medicine overexpressed or activated Src is present in a high percentage of tumours, Src has therefore been an target for the development of anti-cancer therapies Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information phosphorylation of Y527 leads to the inactivation of c-Src, negative regulation Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endosome
-
Homo sapiens 5768
-
plasma membrane
-
Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [protein]-L-tyrosine Homo sapiens
-
ADP + [protein]-L-tyrosine phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [protein]-L-tyrosine
-
Homo sapiens ADP + [protein]-L-tyrosine phosphate
-
?

Synonyms

Synonyms Comment Organism
Src tyrosine kinase
-
Homo sapiens