Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | autophosphorylation of Y416 leads to the activation of c-Src | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | overexpressed or activated Src is present in a high percentage of tumours, Src has therefore been an target for the development of anti-cancer therapies | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | phosphorylation of Y527 leads to the inactivation of c-Src, negative regulation | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endosome | - |
Homo sapiens | 5768 | - |
plasma membrane | - |
Homo sapiens | 5886 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [protein]-L-tyrosine | Homo sapiens | - |
ADP + [protein]-L-tyrosine phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | - |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [protein]-L-tyrosine | - |
Homo sapiens | ADP + [protein]-L-tyrosine phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Src tyrosine kinase | - |
Homo sapiens |