Activating Compound | Comment | Organism | Structure |
---|---|---|---|
epithelial growth factor receptor | - |
Homo sapiens | |
insulin-like growth factor 1 receptor | - |
Homo sapiens | |
additional information | phosphorylation of Y245 and Y412 leads to the activation of Abl kinase | Homo sapiens | |
platelet-derived growth factor receptor | - |
Homo sapiens | |
Src | activated Src kinase in aggressive breast cancer cell lines can activate c-Abl kinase | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | the activated c-Abl tyrosine kinase plays an important role in malignant solid tumors of lung and breast, mutant forms are involved in hematopoietic malignancies such as chronic myeloid leukemia, CML | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Bcr protein | negative regulator | Homo sapiens | |
F-actin | negative regulator | Homo sapiens | |
Fus1 protein | negative regulator | Homo sapiens | |
imatinib mesylate | Gleevec | Homo sapiens | |
additional information | c-Abl is downregulated in part by intramolecular interactions that provide autoinhibitory kinase effects | Homo sapiens | |
PAG protein | negative regulator | Homo sapiens | |
phosphoinositide | negative regulator | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | the oncogenic effects of Abl are believed to reside in cytoplasmic forms of c-Abl | Homo sapiens | 5737 | - |
nucleus | - |
Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [protein]-L-tyrosine | Homo sapiens | - |
ADP + [protein]-L-tyrosine phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | - |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | - |
Homo sapiens | - |
MDA-MB-435 cell | - |
Homo sapiens | - |
NCI-H1299 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [protein]-L-tyrosine | - |
Homo sapiens | ADP + [protein]-L-tyrosine phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
c-ABL | - |
Homo sapiens |
c-Abl tyrosine kinase | - |
Homo sapiens |