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Literature summary for 2.7.10.2 extracted from

  • Murayama, K.; Kato-Murayama, M.; Mishima, C.; Akasaka, R.; Shirouzu, M.; Fukui, Y.; Yokoyama, S.
    Crystal structure of the Brutons tyrosine kinase PH domain with phosphatidylinositol (2008), Biochem. Biophys. Res. Commun., 377, 23-28.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
the Btk PH domain is expressed in Spodoptera frugiperda Sf9 insect cells using the baculovirus expression system Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
the crystal structure of a Btk fragment consisting of the PH domain and the Btk motif in complex with dibutylyl-phosphatidylinositol-3,4,5-triphosphate is determined Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
Homo sapiens 5886
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [protein]-L-tyrosine Homo sapiens
-
ADP + [protein]-L-tyrosine phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q06187
-
-

Purification (Commentary)

Purification (Comment) Organism
using a HiTrap SP, a Mono S, and a HiLoad Superdex75 column Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [protein]-L-tyrosine
-
Homo sapiens ADP + [protein]-L-tyrosine phosphate
-
?

Subunits

Subunits Comment Organism
homodimer the Btk PH domain forms a homodimer Homo sapiens

Synonyms

Synonyms Comment Organism
Bruton's tyrosine kinase
-
Homo sapiens
Bruton's tyrosine kinase PH domain
-
Homo sapiens
Btk
-
Homo sapiens