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Literature summary for 2.7.10.2 extracted from
- Spleen tyrosine kinase (Syk), a novel target of curcumin, is required for B lymphoma growth (2007), J. Immunol., 178, 111-121.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | Akt is activated by phosphorylation at Ser473 and at Thr308 | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| curcumin | downregulates and inhibits tyrosine kinase Syk, which leads to inhibition of Akt, in lymphoma cells, curcumin causes growth inhibition of B lymphoma, mechanism, overview | Homo sapiens |  |
| curcumin | downregulates and inhibits tyrosine kinase Syk, which leads to inhibition of Akt, in lymphoma cells, curcumin causes growth inhibition of B lymphoma, mechanism, overview | Mus musculus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + Bad protein | Mus musculus | substrate of Akt | ADP + phosphotyrosinyl Bad protein | - |
? | |
| ATP + Bad protein | Homo sapiens | substrate of Akt | ADP + phosphotyrosinyl Bad protein | - |
? | |
| ATP + glycogen synthase kinase 3beta | Mus musculus | substrate of Akt | ADP + phosphotyrosinyl glycogen synthase kinase 3beta | - |
? | |
| ATP + glycogen synthase kinase 3beta | Homo sapiens | substrate of Akt | ADP + phosphotyrosinyl glycogen synthase kinase 3beta | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | Akt is activated by phosphorylation at Ser473 and at Thr308 | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| B-cell lymphoma cell | Akt and Syk, the latter is constitutively activated in primary tumor cells | Homo sapiens | - |
| B-cell lymphoma cell | Ly-10 DLBCL cells or WEHI-231 cells, Akt and Syk, the latter is constitutively activated in primary tumor cells | Mus musculus | - |
| spleen | Syk | Mus musculus | - |
| spleen | Syk | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + Bad protein | substrate of Akt | Mus musculus | ADP + phosphotyrosinyl Bad protein | - |
? | |
| ATP + Bad protein | substrate of Akt | Homo sapiens | ADP + phosphotyrosinyl Bad protein | - |
? | |
| ATP + glycogen synthase kinase 3beta | substrate of Akt | Mus musculus | ADP + phosphotyrosinyl glycogen synthase kinase 3beta | - |
? | |
| ATP + glycogen synthase kinase 3beta | substrate of Akt | Homo sapiens | ADP + phosphotyrosinyl glycogen synthase kinase 3beta | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AKT | - |
Mus musculus |
| AKT | - |
Homo sapiens |
| Syk | - |
Mus musculus |
| Syk | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 22 | - |
assay at room temperature | Mus musculus |
| 22 | - |
assay at room temperature | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Mus musculus | |
| ATP | - |
Homo sapiens | |
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