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Literature summary for 2.7.10.2 extracted from

  • Rider, L.; Shatrova, A.; Feener, E.P.; Webb, L.; Diakonova, M.
    JAK2 tyrosine kinase phosphorylates PAK1 and regulates PAK1 activity and functions (2007), J. Biol. Chem., 282, 30985-30996.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
prolactin activates Jak2 Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression of wild-type and mutant JAK2 Homo sapiens

Protein Variants

Protein Variants Comment Organism
K882E kinase-inactive JAK2 mutant Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + PAK1 Homo sapiens Jak2 is involved in the regulation of serine-threonine kinase PAK1, maximal cell motility is required for tyrosyl phosphorylation of PAK1 ADP + phospho-L-tyrosinyl-PAK1
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + PAK1 Jak2 is involved in the regulation of serine-threonine kinase PAK1, maximal cell motility is required for tyrosyl phosphorylation of PAK1 Homo sapiens ADP + phospho-L-tyrosinyl-PAK1
-
?
ATP + PAK1 a serine-threonine kinase, phosphorylation at Y153, Y201, and Y285 activates PAK1, no activation of PAK1 mutants Y153F,Y201F,Y285F, mutational analysis of phosphorylation sites,overview Homo sapiens ADP + phospho-L-tyrosinyl-PAK1
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?

Synonyms

Synonyms Comment Organism
JAK2
-
Homo sapiens
JAK2 tyrosine kinase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens