Cloned (Comment) | Organism |
---|---|
Jak2, DNA and amino acid sequence determination and analysis, oc-expression of wild-type Jak2 with increasing amounts of mutant W1038G/E1024A or mutant W1038G/E1024R, the latter is more potent in reducing wild-type enzyme actiivty in a dominant-negative way, overview | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
W1038G/E1046A | site-directed mutagenesis, an inactive dominant-negative mutant, construction of transgenic mice, heterologous mutants show reduced enzyme activity and an unaltered phenotype, overview | Mus musculus |
W1038G/E1046R | site-directed mutagenesis, an inactive dominant-negative mutant, construction of transgenic mice, heterologous mutants show reduced enzyme activity and an unaltered phenotype, overview | Mus musculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | the enzyme is involved in cytokine signaling | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q62120 | Jak2 | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | the enzyme is activated via phosphorylation at the activation loop, also by autophosphorylation | Mus musculus |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate | residue W1038 is essential for catalytic activity | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme is involved in cytokine signaling | Mus musculus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | molecular modeling of the active site of wild-type and mutant Jak2, overview | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
JAK2 | - |
Mus musculus |
Janus kinase 2 | - |
Mus musculus |
More | the enzyme belongs to the Janus family of tyrosine kinases | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Mus musculus |