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Literature summary for 2.7.10.2 extracted from

  • Ovrevik, J.; Lag, M.; Schwarze, P.; Refsnes, M.
    p38 and Src-ERK1/2 pathways regulate crystalline silica-induced chemokine release in pulmonary epithelial cells (2004), Toxicol. Sci., 81, 480-490.
    View publication on PubMed
Search for more literature for 2.7.10.2

Inhibitors

Inhibitors Comment Organism Structure
4-amino-5-(4-chlorophenyl)-7-(tert-butyl)pyrazolo[3,4-d] pyrimidine i.e. pp2, ihibits Src family PTKs Homo sapiens
4-amino-5-(4-chlorophenyl)-7-(tert-butyl)pyrazolo[3,4-d] pyrimidine i.e. pp2, inhibits Src family PTKs Rattus norvegicus
genistein
-
 Homo sapiens
genistein
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus the Src tyrosine kinase regulates and stimulates silica particle formation in epithelium which induces chemokine KIP-2 release activating the signaling cascade via phosphorylation of MAPK and ERK, overview ?
-
 ?
additional information Homo sapiens the Src tyrosine kinase regulates and stimulates silica particle formation in lung epithelium which induces interleukin-8 release activating the signaling cascade via phosphorylation of MAPK and ERK, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell epithelial lung cell line Homo sapiens
-
alveolar cell type II
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the Src tyrosine kinase regulates and stimulates silica particle formation in epithelium which induces chemokine KIP-2 release activating the signaling cascade via phosphorylation of MAPK and ERK, overview Rattus norvegicus ?
-
 ?
additional information the Src tyrosine kinase regulates and stimulates silica particle formation in lung epithelium which induces interleukin-8 release activating the signaling cascade via phosphorylation of MAPK and ERK, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
More member of the Src kinase family Homo sapiens
More member of the Src kinase family Rattus norvegicus
Src tyrosine kinase
-
 Homo sapiens
Src tyrosine kinase
-
 Rattus norvegicus