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Literature summary for 2.7.10.2 extracted from

  • Kim, J.; Ogata, Y.; Feldman, R.A.
    Fes tyrosine kinase promotes survival and terminal granulocyte differentiation of factor-dependent myeloid progenitors (32D) and activates lineage-specific transcription factors (2003), J. Biol. Chem., 278, 14978-14984.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of activated allele of Fes tyrosine kinase, Fesact, encoded by c-fps/es proto-oncogene, in factor-dependent 32D cells preventing their apoptotic death after interleukin-3 removal followd by granulocytic differentiation, factor dependency remains for proliferation, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens Fes tyrosine kinase promotes survival and terminal granulocyte differentiation of factor-dependent myeloid progenitors (32D) and activates lineage-specific transcription factors, e.g. CCAAT/enhancer-binding protein-alpha and STAT3, down-regulation of macrophage marker F4/80 ?
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Fes tyrosine kinase promotes survival and terminal granulocyte differentiation of factor-dependent myeloid progenitors (32D) and activates lineage-specific transcription factors, e.g. CCAAT/enhancer-binding protein-alpha and STAT3, down-regulation of macrophage marker F4/80 Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
Fes
-
Homo sapiens
Fes tyrosine kinase
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Homo sapiens