Literature summary for 2.7.10.2 extracted from

Grossmann, A.H.; Kolibaba, K.S.; Willis, S.G.; Corbin, A.S.; Langdon, W.S.; Deininger, M.W.; Druker, B.J.
Catalytic domains of tyrosine kinases determine the phosphorylation sites within c-Cbl (2004), FEBS Lett., 577, 555-562.

Search for more literature for 2.7.10.2

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	Syk requires 20 mM, Fyn and Abl require 10 mM	Homo sapiens
Mn2+	Syk requires 5 mM, Fyn requires 10 mM	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + [c-Cbl]-L-tyrosine	Homo sapiens	proto-oncogenic PTK protein substrate	ADP + [c-Cbl]-L-tyrosine phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + [c-Cbl]-L-tyrosine	proto-oncogenic PTK protein substrate	Homo sapiens	ADP + [c-Cbl]-L-tyrosine phosphate	-	?
ATP + [c-Cbl]-L-tyrosine	activity and phosphorylation patterns of Syk, Fyn, and Abl with recombinant wild-type and mutant Y700F, Y731F, and Y774F c-Cbl proteins, phosphorylation site preferences are determined by interaction of the enzymes' SH2 domain with the substrate via p85, a phosphatidylinositol 3-kinase, overview	Homo sapiens	ADP + [c-Cbl]-L-tyrosine phosphate	-	?

Synonyms

Synonyms	Comment	Organism
Abl	-	Homo sapiens
Fyn	-	Homo sapiens
More	Syk, Fyn, and Abl belong to the Src family of PTKs	Homo sapiens
Protein tyrosine kinase	-	Homo sapiens
PTK	-	Homo sapiens
Syk	-	Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
22	-	assay at room temperature	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.5	-	assay at	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Homo sapiens

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Release 2023.1 (January 2023)