Application | Comment | Organism |
---|---|---|
pharmacology | ABL protein tyrosine kinase is a target for treatment of chronic myeloid leukemia with imatinib mesylate, synergistic with AG-490, an inhibitor of JAK2 tyrosine kinase signaling | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
genetic analysis of mutations causing cell cycle deregulation, e.g. in mice lacking cyclin-D2, heterozygous D2+/- mice are resistant to BCR/ABL-induced proliferation, overview | Mus musculus |
genetic analysis of mutations causing myeloid malignancies | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
E225K | naturally occurring mutation in the BCR/ABL kinase leading to resistance against inhibitor imatinib mesylate in vivo and in cell culture in vitro | Homo sapiens |
E225V | naturally occurring mutation in the BCR/ABL kinase leading to resistance against inhibitor imatinib mesylate in cell culture in vitro | Homo sapiens |
H396P | naturally occurring mutation in the BCR/ABL kinase leading to resistance against inhibitor imatinib mesylate in cell culture in vitro | Homo sapiens |
T315I | naturally occurring mutation in the BCR/ABL kinase leading to resistance against inhibitor imatinib mesylate in cell culture in vitro | Homo sapiens |
Y253H | naturally occurring mutation in the BCR/ABL kinase leading to resistance against inhibitor imatinib mesylate in cell culture in vitro | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
AG-490 | inhibits JAK2 tyrosine kinase | Homo sapiens | |
imatinib mesylate | 2-phenylaminopyrimidine derivate, i.e. CGP-57148, inhibits BCR/ABL kinase, used in antityrosine kinase therapy of myeloid leukemia | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | protein tyrosine kinases are involved in downstream signaling pathways, e.g. BCR/ABL kinase in the phosphatidylinositol 3'-kinase pathway, required for regulation of cell differentiation and cell cycle regulation, BCR/ABL and several other constitutive protein tyrosine kinases are activated in myeloid malignancies, overview, protein deregulation probable due to fusion gene formation because of chromosomal translocations or as distinct gain-of-function point mutations, autophosphorylation of BCR/ABL kinase at Tyr177 is essential for myeloid leukomogenesis in vivo, expression of BCR/ABL kinase leads to functional downregulation of the basal transcription factor TFIIH involved in nucleotide excision DNA repair pathway, and to activation of RAD51 also involved in DNA repair, overview | ? | - |
? | |
additional information | Mus musculus | protein tyrosine kinases are involved in downstream signaling pathways, e.g. BCR/ABL kinase in the phosphatidylinositol 3'-kinase pathway, required for regulation of cell differentiation and cell cycle regulation, expression of BCR/ABL kinase leads to functional downregulation of the basal transcription factor TFIIH involved in nucleotide excision DNA repair pathway, and to activation of RAD51 also involved in DNA repair, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | tyrosine autophosphorylation of BCR/ABL kinase | Mus musculus |
phosphoprotein | tyrosine autophosphorylation of BCR/ABL kinase at Tyr177 | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bone marrow | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | protein tyrosine kinases are involved in downstream signaling pathways, e.g. BCR/ABL kinase in the phosphatidylinositol 3'-kinase pathway, required for regulation of cell differentiation and cell cycle regulation, BCR/ABL and several other constitutive protein tyrosine kinases are activated in myeloid malignancies, overview, protein deregulation probable due to fusion gene formation because of chromosomal translocations or as distinct gain-of-function point mutations, autophosphorylation of BCR/ABL kinase at Tyr177 is essential for myeloid leukomogenesis in vivo, expression of BCR/ABL kinase leads to functional downregulation of the basal transcription factor TFIIH involved in nucleotide excision DNA repair pathway, and to activation of RAD51 also involved in DNA repair, overview | Homo sapiens | ? | - |
? | |
additional information | protein tyrosine kinases are involved in downstream signaling pathways, e.g. BCR/ABL kinase in the phosphatidylinositol 3'-kinase pathway, required for regulation of cell differentiation and cell cycle regulation, expression of BCR/ABL kinase leads to functional downregulation of the basal transcription factor TFIIH involved in nucleotide excision DNA repair pathway, and to activation of RAD51 also involved in DNA repair, overview | Mus musculus | ? | - |
? | |
additional information | the BCR/ABL kinase performs tyrosine autophosphorylation, mechanism | Mus musculus | ? | - |
? | |
additional information | the BCR/ABL kinase performs tyrosine autophosphorylation, mechanism | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Abl protein tyrosine kinase | - |
Homo sapiens |
BCR/ABL kinase | - |
Mus musculus |
BCR/ABL kinase | - |
Homo sapiens |
JAK2 tyrosine kinase | - |
Homo sapiens |
Protein tyrosine kinase | - |
Mus musculus |
Protein tyrosine kinase | - |
Homo sapiens |
PTK | - |
Mus musculus |
PTK | - |
Homo sapiens |