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Literature summary for 2.7.10.2 extracted from

  • Ruschel, A.; Ullrich, A.
    Protein tyrosine kinase Syk modulates EGFR signalling in human mammary epithelial cells (2004), Cell. Signal., 16, 1249-1261.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of VSV-tagged wild-type Syk and catalytically inactive mutant Syk K- in MCF-10A cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information epidermal growth factor receptor EGFR induces Syk inhibition Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm Syk main localization Homo sapiens 5737
-
membrane Syk is colocalized with EGFR Homo sapiens 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Homo sapiens
Mn2+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens spleen tyrosine kinase Syk modulates epidermal growth factor receptor EGFR signalling in mammary epithelial cells acting as a negative controle element, regulation of EGFR by activation of the autophosphorylation activity of EGFR, but not of HER2 and HER3, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast epithelium, Syk occurs in MDA-MB-468 cells, but not in BT-549 cells Homo sapiens
-
breast cancer cell
-
Homo sapiens
-
epithelium
-
Homo sapiens
-
mammary gland
-
Homo sapiens
-
MCF-10A cell breast epithelial cell line Homo sapiens
-
MDA-MB-468 cell breast cancer cell line Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information spleen tyrosine kinase Syk modulates epidermal growth factor receptor EGFR signalling in mammary epithelial cells acting as a negative controle element, regulation of EGFR by activation of the autophosphorylation activity of EGFR, but not of HER2 and HER3, overview Homo sapiens ?
-
?
additional information Syk performs autophosphorylation Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
Protein tyrosine kinase
-
Homo sapiens
PTK
-
Homo sapiens
Spleen tyrosine kinase
-
Homo sapiens
Syk
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens