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Literature summary for 2.7.10.2 extracted from

  • Takashima, Y.; Delfino, F.J.; Engen, J.R.; Superti-Furga, G.; Smithgall, T.E.
    Regulation of c-Fes tyrosine kinase activity by coiled-coil and SH2 domains: analysis with Saccharomyces cerevisiae (2003), Biochemistry, 42, 3567-3574.
    View publication on PubMed
Search for more literature for 2.7.10.2

Cloned(Commentary)

Cloned (Comment) Organism
proto-oncogene c-fes, overexpression of wild-type and C-terminally FLAG-tagged mutant enzymes in Saccharomyces cerevisiae strain YPH 499 Homo sapiens

Protein Variants

Protein Variants Comment Organism
K590E site-directed mutagenesis, inactive mutant enzyme Homo sapiens
L145P site-directed mutagenesis, mutation in the first coiled-coil motif, mutation leads to growth arrest of yeast cells Homo sapiens
L145P/L334P site-directed mutagenesis, mutation in the first and second coiled-coil motifs, mutations lead to growth arrest of yeast cells Homo sapiens
L334P site-directed mutagenesis, mutation in the second coiled-coil motif, mutation leads to growth arrest of yeast cells Homo sapiens
additional information construction of chimeric mutant Fes by exchanging the wild-type SH2 domain for the SH2 domains of v-Src, Fps, or p120 Ras, construction of deletion mutants lacking either the first or the second coiled-coil motifs eliminating tyrosine kinase activity and causing growth arrest of yeast cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the Fes tyrosine kinase is regulated via its SH2 domain ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the Fes tyrosine kinase is regulated via its SH2 domain Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
c-Fes protein-tyrosine kinase
-
 Homo sapiens
c-Fes tyrosine kinase
-
 Homo sapiens
Fes
-
 Homo sapiens