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Literature summary for 2.7.10.2 extracted from
- Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyr15 (1993), EMBO J., 12, 75-85.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + p34cdc2 | Homo sapiens | Wee1 kinase inhibits mitosis by directly phosphorylating p34cdc2 on Y15 | ADP + phosphorylated p34cdc2 | - |
? |  |
| additional information | Homo sapiens | blocks cell division when overexpressed in Hela cells | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P30291 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cell culture | HeLa cells | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + p34cdc2 | phosphorylated exclusively on Y15 | Homo sapiens | ADP + phosphorylated p34cdc2 | - |
? | |
| ATP + p34cdc2 | Wee1 kinase inhibits mitosis by directly phosphorylating p34cdc2 on Y15 | Homo sapiens | ADP + phosphorylated p34cdc2 | - |
? | |
| additional information | blocks cell division when overexpressed in Hela cells | Homo sapiens | ? | - |
? | |
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