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Literature summary for 2.7.10.2 extracted from
- The solution structure of the Raf-1 cysteine-rich domain: a novel ras and phospholipid binding site (1996), Proc. Natl. Acad. Sci. USA, 93, 8312-8317.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a protein | Homo sapiens | the enzyme is a downstream effector of activated Ras. Interaction with Ras leads to Raf-1 activation and results in transduction of cell growth and differentiation signals | ADP + a phosphoprotein | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P04049 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a protein | the enzyme is a downstream effector of activated Ras. Interaction with Ras leads to Raf-1 activation and results in transduction of cell growth and differentiation signals | Homo sapiens | ADP + a phosphoprotein | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| RAF proto-oncogene serine/threonine-protein kinase | - |
Homo sapiens |
| Raf-1 protein kinase | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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