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Literature summary for 2.7.10.2 extracted from

  • Toshima, J.; Toshima, J.Y.; Takeuchi, K.; Mori, R.; Mizuno, K.
    Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells (2001), J. Biol. Chem., 276, 31449-31458.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information mutant lacking the C-terminal noncatalytic region has about a 10fold higher kinase activity in vitro and, when expressed in HeLa cells, induces punctate actin aggregates in the cytoplasm and unusual condensation and fragmentation of nuclei, followed by apoptosis Rattus norvegicus
additional information mutant lacking the C-terminal noncatalytic region has about a 10fold higher kinase activity in vitro and, when expressed in HeLa cells, induces punctate actin aggregates in the cytoplasm and unusual condensation and fragmentation of nuclei, followed by apoptosis Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus localized mainly in Rattus norvegicus 5634
-
nucleus localized mainly in Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a protein Rattus norvegicus the enzyme induces formation of actin stress fibers and focal adhesions ADP + a phosphoprotein
-
?
ATP + a protein Homo sapiens the enzyme induces formation of actin stress fibers and focal adhesions ADP + a phosphoprotein
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q96S53
-
-
Rattus norvegicus Q924U5
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Sertoli cell predominant expression in Rattus norvegicus
-
Sertoli cell predominant expression in Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a protein the enzyme induces formation of actin stress fibers and focal adhesions Rattus norvegicus ADP + a phosphoprotein
-
?
ATP + a protein the enzyme induces formation of actin stress fibers and focal adhesions Homo sapiens ADP + a phosphoprotein
-
?
ATP + cofilin phosphorylation specifically at Ser-3 Rattus norvegicus ADP + phosphorylated cofilin
-
?
ATP + cofilin phosphorylation specifically at Ser-3 Homo sapiens ADP + phosphorylated cofilin
-
?

Synonyms

Synonyms Comment Organism
TESK2
-
Rattus norvegicus
TESK2
-
Homo sapiens
testis-specific protein kinase 2
-
Rattus norvegicus
testis-specific protein kinase 2
-
Homo sapiens