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Literature summary for 2.7.10.1 extracted from

  • Kotani, H.; Ebi, H.; Kitai, H.; Nanjo, S.; Kita, K.; Huynh, T.; Ooi, A.; Faber, A.; Mino-Kenudson, M.; Yano, S.
    Co-active receptor tyrosine kinases mitigate the effect of FGFR inhibitors in FGFR1-amplified lung cancers with low FGFR1 protein expression (2016), Oncogene, 35, 3587-3597.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
AZD4547
-
 Homo sapiens
NVP-BGJ398
-
 Homo sapiens
PD-173074
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a [protein]-L-tyrosine Homo sapiens
-
 ADP + a [protein]-L-tyrosine phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Calu-3 cell
-
 Homo sapiens
-
DMS-114 cell
-
 Homo sapiens
-
HCC-95 cell
-
 Homo sapiens
-
NCI-H1581 cell
-
 Homo sapiens
-
NCI-H1703 cell
-
 Homo sapiens
-
NCI-H520 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a [protein]-L-tyrosine
-
 Homo sapiens ADP + a [protein]-L-tyrosine phosphate
-
 ?

Synonyms

Synonyms Comment Organism
FGFR1
-
 Homo sapiens
fibroblast growth factor receptor
-
 Homo sapiens
RTK
-
 Homo sapiens