Application | Comment | Organism |
---|---|---|
synthesis | methodology for generating milligram amounts of functional Eph tyrosine kinase receptor using the protein engineering approach of expressed protein ligation. Stimulation with ligand induces efficient autophosphorylation of the semisynthetic Eph construct. The in vitro phosphorylation of key Eph tyrosine residues upon ligand-induced activation follows a precise and unique order of phosphorylation of the Eph tyrosines in the kinase activation process | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P54764 | EPHA4 | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | Eph receptor tyrosine kinases are activated upon ephrin binding via a sequential and ordered autophosphorylation process where residue YJM2 is phosphorylated first, followed by YJM1, and, finally by Yact. The Eph kinase activity most closely correlates with the phosphorylation status of the juxtamembrane region and not that of the activation loop. Eph kinase activity is primarily correlated with phosphorylation of residue YJM2 and not of the adjacent YJM1 | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
Eph receptor tyrosine kinase | - |
Homo sapiens |
EPHA4 | - |
Homo sapiens |
ephrin type-A receptor 4 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | Eph receptor tyrosine kinases are activated upon ephrin binding via a sequential and ordered autophosphorylation process where residue YJM2 is phosphorylated first, followed by YJM1, and, finally by Yact. The Eph kinase activity most closely correlates with the phosphorylation status of the juxtamembrane region and not that of the activation loop. Eph kinase activity is primarily correlated with phosphorylation of residue YJM2 and not of the adjacent YJM1 | Homo sapiens |