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Literature summary for 2.7.10.1 extracted from
- Activation of the orphan receptor tyrosine kinase ALK by zinc (2010), Biochem. Biophys. Res. Commun., 398, 702-706.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in HEK-293 cell | Homo sapiens |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | presence of Zn2+ at 0.1 mM rapidly activates isoform ALK. This activation is dependent of ALK tyrosine kinase activity and dimerization of the receptor but is independent of Src family kinase activity. Addition of sodium pyrithione, a zinc ionophore, leads to a further activation of ALK. This stronger activation is dependent of Src family kinase but independent of ALK activity and dimerization | Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ALK | - |
Homo sapiens |
| Anaplastic lymphoma kinase | - |
Homo sapiens |
| orphan receptor tyrosine kinase | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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