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Literature summary for 2.7.10.1 extracted from

  • Buttar, N.S.; DeMars, C.J.; Lomberk, G.; Rizvi, S.; Bonilla-Velez, J.; Achra, S.; Rashtak, S.; Wang, K.K.; Fernandez-Zapico, M.E.; Urrutia, R.
    Distinct role of Kruppel-like factor 11 in the regulation of prostaglandin E2 biosynthesis (2010), J. Biol. Chem., 285, 11433-11444.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
PD168393 complete inhibition at 0.01 mM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
Egfr
-
 Homo sapiens
epidermal growth factor receptor
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function Kruppel-like factor 11 inhibits prostaglandin E2 synthesis via transcriptional silencing of the promoter of cytosolic phospholipase A2, this function of Kruppel-like factor 11 can be reversed by epidermal growth factor receptor-AKT-mediated post-translational modification of threonine 56 Homo sapiens