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Literature summary for 2.7.10.1 extracted from
- Abl tyrosine kinase regulates endocytosis of the epidermal growth factor receptor (2006), J. Biol. Chem., 281, 32714-32723.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| AbI kinase | activated Abl kinase phosphorylates the EGFR at specific sites and uncouples the receptor from ligand-mediated internalization | Homo sapiens | |
| dynamin K44A | reduces EGFR internalization to 40% | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a [protein]-L-tyrosine | Homo sapiens | - |
ADP + a [protein]-L-tyrosine phosphate | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HEK-293T cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a [protein]-L-tyrosine | - |
Homo sapiens | ADP + a [protein]-L-tyrosine phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Egfr | - |
Homo sapiens |
| epidermal growth factor receptor | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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