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Literature summary for 2.7.10.1 extracted from

  • Mehdi, M.Z.; Pandey, N.R.; Pandey, S.K.; Srivastava, A.K.
    H2O2-induced phosphorylation of ERK1/2 and PKB requires tyrosine kinase activity of insulin receptor and c-Src (2005), Antioxid. Redox Signal., 7, 1014-1020.
    View publication on PubMed
Search for more literature for 2.7.10.1

Activating Compound

Activating Compound Comment Organism Structure
hydrogen peroxide activates the autophosphorylation and protein tyrosine phosphorylation activities of the insulin receptor, and thus the insulin receptor signaling pathway, overview Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of wild-type enzyme CHO-IR and K1018A mutant enzyme CHO-1018 in CHO cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
K1018A construction of a defective-enzyme mutant CHO-1018 cell line which shows a loss in ATP-binding activity and thus in PTK function Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens insulin- or H2O2-induced activation by autophosphorylation of the insulin receptor initiates the IR signaling pathway which includes phosphorylation of extracellular signal-regulated kinases 1 and 2, i.e. ERK1 and ERK2, protein kinase B, and glycogen synthase kinase 3-beta ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein activation via insulin-induced autophosphorylation, can also be induced by H2O2 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information insulin- or H2O2-induced activation by autophosphorylation of the insulin receptor initiates the IR signaling pathway which includes phosphorylation of extracellular signal-regulated kinases 1 and 2, i.e. ERK1 and ERK2, protein kinase B, and glycogen synthase kinase 3-beta Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
More the tyrosine kinase activity is located on the beta-subunit of the insulin receptor Homo sapiens

Synonyms

Synonyms Comment Organism
insulin receptor protein tyrosine kinase
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 Homo sapiens
insulin receptor-beta subunit
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 Homo sapiens
iR-beta subunit
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 Homo sapiens
IR-PTK
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 Homo sapiens
non-receptor protein tyrosine kinase
-
 Homo sapiens