Activating Compound | Comment | Organism | Structure |
---|---|---|---|
angiotensin II | induces transactivation of epidermal growth factor receptor, mechanism | Homo sapiens | |
additional information | reactive oxygen species, such as O2.- and H2O2, function as mitogenic mediators of activated growth-factor-receptor signaling | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ebselen | - |
Bos taurus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | transmembrane proteins with a single transmembrane pass, a cytoplasmic domain, and an extracellular domain, overview | Homo sapiens | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | activation of PDGF receptor growth factor results in increased intracellular Ca2+ flux and cytoplasmic pH changes, enzyme stimulates generation of reactive oxygen species, such as O2.- and H2O2, which function as mitogenic mediators of activated growth-factor-receptor signaling, overview, the EGFR signaling pathway functions in many cellular processes, including proliferation, cell migration, and apoptosis, signaling pathways, overview | ? | - |
? | |
additional information | Bos taurus | activation of PDGF receptor growth factor results in increased intracellular Ca2+ flux and cytoplasmic pH changes, enzyme stimulates generation of reactive oxygen species, which function as mitogenic mediators of activated growth-factor-receptor signaling, overview, the EGFR signaling pathway functions in many cellular processes, including proliferation, cell migration, and apoptosis, signaling pathways, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Homo sapiens | - |
2 isozymes PDGF-alpha receptor and PDGF-beta receptor, 4 isozymes FGFR-1, FGFR-2, FGFR-3, and FGFR-4 | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | epidermal growth factor receptor contains a glycosylated extracellular domain | Homo sapiens |
phosphoprotein | 7 autophosphorylation sites, specific binding sites for Src family protein kinases, in PDGF-beta receptor, epidermal growth factor receptor is autophosphorylated after ligand binding forming dimers or oligomers with itself or other members of the Erb family | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-431 cell | epidermoid carcinoma | Homo sapiens | - |
aorta | smooth muscle | Homo sapiens | - |
chondrocyte | fibroblast growth factor receptor | Homo sapiens | - |
endothelial cell | - |
Homo sapiens | - |
fibroblast | lung | Homo sapiens | - |
heart | vascular endothelial growth factor receptor | Homo sapiens | - |
Hep-G2 cell | - |
Homo sapiens | - |
lung | fibroblast | Homo sapiens | - |
macrophage | - |
Homo sapiens | - |
myocyte | tracheal | Bos taurus | - |
neutrophil | - |
Homo sapiens | - |
placenta | - |
Homo sapiens | - |
smooth muscle | aortic | Homo sapiens | - |
trachea | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | activation of PDGF receptor growth factor results in increased intracellular Ca2+ flux and cytoplasmic pH changes, enzyme stimulates generation of reactive oxygen species, such as O2.- and H2O2, which function as mitogenic mediators of activated growth-factor-receptor signaling, overview, the EGFR signaling pathway functions in many cellular processes, including proliferation, cell migration, and apoptosis, signaling pathways, overview | Homo sapiens | ? | - |
? | |
additional information | activation of PDGF receptor growth factor results in increased intracellular Ca2+ flux and cytoplasmic pH changes, enzyme stimulates generation of reactive oxygen species, which function as mitogenic mediators of activated growth-factor-receptor signaling, overview, the EGFR signaling pathway functions in many cellular processes, including proliferation, cell migration, and apoptosis, signaling pathways, overview | Bos taurus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | platelet-derived growth factor receptor is a homo- or heterodimer wih A and B chains being assembled in different combinations, i.e. PDGF-alpha receptor or PDGF-beta receptor | Homo sapiens |
monomer | epidermal growth factor receptor | Homo sapiens |
oligomer | epidermal growth factor receptor is autophosphorylated after ligand binding forming dimers or oligomers with itself or other members of the Erb family | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
Egfr | - |
Homo sapiens |
ephrine receptor | - |
Homo sapiens |
epidermal growth factor receptor | - |
Homo sapiens |
FGFR | - |
Homo sapiens |
fibroblast growth factor receptor | - |
Homo sapiens |
hepatocyte growth factor receptor | - |
Homo sapiens |
insulin receptor | - |
Homo sapiens |
insulin-like growth factor receptor | - |
Homo sapiens |
macrophage colony-stimulating factor receptor | - |
Homo sapiens |
More | epidermal growth factor receptor is a member of the Erb family | Homo sapiens |
nerve growth factor receptor | - |
Homo sapiens |
PDGF-alpha receptor | - |
Homo sapiens |
PDGF-beta receptor | - |
Homo sapiens |
PDGFR | - |
Homo sapiens |
PDGFR | - |
Bos taurus |
platelet-derived growth factor receptor | - |
Homo sapiens |
platelet-derived growth factor receptor | - |
Bos taurus |
receptor tyrosine kinase | - |
Homo sapiens |
RPTK | - |
Homo sapiens |
vascular endothelial growth factor receptor | - |
Homo sapiens |
VEGFR | - |
Homo sapiens |