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Literature summary for 2.7.10.1 extracted from

  • Aslan, M.; Ozben, T.
    Oxidants in receptor tyrosine kinase signal transduction pathways (2003), Antioxid. Redox Signal., 5, 781-788.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
angiotensin II induces transactivation of epidermal growth factor receptor, mechanism Homo sapiens
additional information reactive oxygen species, such as O2.- and H2O2, function as mitogenic mediators of activated growth-factor-receptor signaling Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
ebselen
-
Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane transmembrane proteins with a single transmembrane pass, a cytoplasmic domain, and an extracellular domain, overview Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens activation of PDGF receptor growth factor results in increased intracellular Ca2+ flux and cytoplasmic pH changes, enzyme stimulates generation of reactive oxygen species, such as O2.- and H2O2, which function as mitogenic mediators of activated growth-factor-receptor signaling, overview, the EGFR signaling pathway functions in many cellular processes, including proliferation, cell migration, and apoptosis, signaling pathways, overview ?
-
?
additional information Bos taurus activation of PDGF receptor growth factor results in increased intracellular Ca2+ flux and cytoplasmic pH changes, enzyme stimulates generation of reactive oxygen species, which function as mitogenic mediators of activated growth-factor-receptor signaling, overview, the EGFR signaling pathway functions in many cellular processes, including proliferation, cell migration, and apoptosis, signaling pathways, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Homo sapiens
-
2 isozymes PDGF-alpha receptor and PDGF-beta receptor, 4 isozymes FGFR-1, FGFR-2, FGFR-3, and FGFR-4
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein epidermal growth factor receptor contains a glycosylated extracellular domain Homo sapiens
phosphoprotein 7 autophosphorylation sites, specific binding sites for Src family protein kinases, in PDGF-beta receptor, epidermal growth factor receptor is autophosphorylated after ligand binding forming dimers or oligomers with itself or other members of the Erb family Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
A-431 cell epidermoid carcinoma Homo sapiens
-
aorta smooth muscle Homo sapiens
-
chondrocyte fibroblast growth factor receptor Homo sapiens
-
endothelial cell
-
Homo sapiens
-
fibroblast lung Homo sapiens
-
heart vascular endothelial growth factor receptor Homo sapiens
-
Hep-G2 cell
-
Homo sapiens
-
lung fibroblast Homo sapiens
-
macrophage
-
Homo sapiens
-
myocyte tracheal Bos taurus
-
neutrophil
-
Homo sapiens
-
placenta
-
Homo sapiens
-
smooth muscle aortic Homo sapiens
-
trachea
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information activation of PDGF receptor growth factor results in increased intracellular Ca2+ flux and cytoplasmic pH changes, enzyme stimulates generation of reactive oxygen species, such as O2.- and H2O2, which function as mitogenic mediators of activated growth-factor-receptor signaling, overview, the EGFR signaling pathway functions in many cellular processes, including proliferation, cell migration, and apoptosis, signaling pathways, overview Homo sapiens ?
-
?
additional information activation of PDGF receptor growth factor results in increased intracellular Ca2+ flux and cytoplasmic pH changes, enzyme stimulates generation of reactive oxygen species, which function as mitogenic mediators of activated growth-factor-receptor signaling, overview, the EGFR signaling pathway functions in many cellular processes, including proliferation, cell migration, and apoptosis, signaling pathways, overview Bos taurus ?
-
?

Subunits

Subunits Comment Organism
dimer platelet-derived growth factor receptor is a homo- or heterodimer wih A and B chains being assembled in different combinations, i.e. PDGF-alpha receptor or PDGF-beta receptor Homo sapiens
monomer epidermal growth factor receptor Homo sapiens
oligomer epidermal growth factor receptor is autophosphorylated after ligand binding forming dimers or oligomers with itself or other members of the Erb family Homo sapiens

Synonyms

Synonyms Comment Organism
Egfr
-
Homo sapiens
ephrine receptor
-
Homo sapiens
epidermal growth factor receptor
-
Homo sapiens
FGFR
-
Homo sapiens
fibroblast growth factor receptor
-
Homo sapiens
hepatocyte growth factor receptor
-
Homo sapiens
insulin receptor
-
Homo sapiens
insulin-like growth factor receptor
-
Homo sapiens
macrophage colony-stimulating factor receptor
-
Homo sapiens
More epidermal growth factor receptor is a member of the Erb family Homo sapiens
nerve growth factor receptor
-
Homo sapiens
PDGF-alpha receptor
-
Homo sapiens
PDGF-beta receptor
-
Homo sapiens
PDGFR
-
Homo sapiens
PDGFR
-
Bos taurus
platelet-derived growth factor receptor
-
Homo sapiens
platelet-derived growth factor receptor
-
Bos taurus
receptor tyrosine kinase
-
Homo sapiens
RPTK
-
Homo sapiens
vascular endothelial growth factor receptor
-
Homo sapiens
VEGFR
-
Homo sapiens