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Literature summary for 2.7.10.1 extracted from

  • Grangeasse, C.; Doublet, P.; Cozzone, A.J.
    Tyrosine phosphorylation of protein kinase Wzc from Escherichia coli K12 occurs through a two-step process (2002), J. Biol. Chem., 277, 7127-7135.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Escherichia coli enzyme is involved in signal transduction ?
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Organism

Organism UniProt Comment Textmining
Escherichia coli P76387
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + tyrosine-protein kinase Wcz The C-terminal domain alone can undergo autophosphorylation and thus appears to harbor the protein-tyrosine kinase activity. By contrast, the N-terminal domain is not phosphorylated when incubated either alone or in the presence of the C-domain, and does not influence the extent of phosphorylation of the C-domain. The C-domain contains six different sites of phosphorylation. Among these, five are located at the C-terminal end of the molecule in the form of a tyrosine cluster Tyr708, Tyr710, Tyr711, Tyr713, and Tyr715, and one site is located upstream, at Tyr569. The Tyr569 residue can autophosphorylate through an intramolecular process, whereas the tyrosine cluster cannot. The phosphorylation of Tyr569 results in an increased protein kinase activity of Wzc, which can, in turn, phosphorylate the five terminal tyrosines through an intermolecular process. It is concluded that protein Wzc autophosphorylates by using a cooperative two-step mechanism that involves both intraphosphorylation and interphosphorylation Escherichia coli ADP + phosphotyrosine-protein kinase Wcz
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additional information enzyme is involved in signal transduction Escherichia coli ?
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Synonyms

Synonyms Comment Organism
tyrosine-protein kinase Wzc
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Escherichia coli