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Literature summary for 2.7.1.91 extracted from

  • Adada, M.M.; Orr-Gandy, K.A.; Snider, A.J.; Canals, D.; Hannun, Y.A.; Obeid, L.M.; Clarke, C.J.
    Sphingosine kinase 1 regulates tumor necrosis factor-mediated RANTES induction through p38 mitogen-activated protein kinase but independently of nuclear factor kappaB activation (2013), J. Biol. Chem., 288, 27667-27679.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
quantitative real-time reverse transcriptase-PCR expression analysis Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information enzyme knockdown in HeLa cells using siRNA cell treatment. Enzyme knockdown significantly enhances RANTES induction in response to TNF with no statistically significant effect on unstimulated levels. RANTES induction is highly NF-kappaB-dependent as shown using NF-kappaB inhibitor BAY 11-7082 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + sphingosine Homo sapiens
-
 ADP + sphingosine 1-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NYA1
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + sphingosine
-
 Homo sapiens ADP + sphingosine 1-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
SK1
-
 Homo sapiens
sphingosine kinase 1
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction loss of sphingosine kinase 1 potentiates induction of the chemokine RANTES (regulated on activation, normal T cell expressed and secreted, also known as CCL5) in HeLa cells stimulated with TNF-alpha despite RANTES induction being highly dependent on the NF-kappaB pathway. Analysis of the mechanism by which SK1 regulates RANTES induction, overview. Loss of SK1 strongly upregulates RANTES independently of effects on NF-kappaB activation, while loss of SK2 does not affect NF-kappaB pathway activation Homo sapiens
physiological function sphingosine kinase 1 produces the pro-survival sphingolipid sphingosine 1-phosphate and is implicated in inflammation, proliferation, and angiogenesis. The enzyme is required for activation of p38 MAPK, but is not required for transcriptional NF-kappaB activity following TNF treatment. But nuclear translocation of NF-kappaB subunits does not require enzyme SK1 Homo sapiens