Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Melatonin | melatonin decreases enzymic activity in PC-3 cells during hypoxia. In addition, Melatonin inhibits the stability of hypoxia inducible factor 1alpha in a time- and concentration-dependent manner and suppresses AKT/glycogen synthase kinase-3beta signaling pathway | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
LNCaP cell | - |
Homo sapiens | - |
PC-3 cell | - |
Homo sapiens | - |
General Information | Comment | Organism |
---|---|---|
physiological function | application of siRNA-SPHK1 and sphingosine kinase inhibitor effectively blocks the expression of hypoxia inducible factor 1alpha, phospho-AKT and vascular endothelial growth factor production in PC-3 cells under hypoxia | Homo sapiens |