Literature summary for 2.7.1.91 extracted from

Hengst, J.; Guilford, J.; Conroy, E.; Wang, X.; Yun, J.
Enhancement of sphingosine kinase 1 catalytic activity by deletion of 21 amino acids from the COOH-terminus (2010), Arch. Biochem. Biophys., 494, 23-31.

Search for more literature for 2.7.1.91

Cloned(Commentary)

Cloned (Comment)	Organism
expression in HEK-293 cell line	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	deletion of 21 amino acids from the COOH-terminus of isoform SphK1, expression of residues 1-363, results in about 2.2fold increase in catalytic activity relative to wild-type SphK1, which is independent of the phosphorylation state of Serine 225 and stimulation by phorbol-12,13-myristic acid. HEK-293 cells stably expressing the truncated protein exhibit enhanced cell growth under serum-deprived cell culture conditions. A further truncated mutant, residues 1-315, displays about 20% of wild-type activity	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

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Release 2023.1 (January 2023)