Literature summary for 2.7.1.91 extracted from

Kono, Y.; Nishiuma, T.; Okada, T.; Kobayashi, K.; Funada, Y.; Kotani, Y.; Jahangeer, S.; Nakamura, S.I.; Nishimura, Y.
Sphingosine kinase 1 regulates mucin production via ERK phosphorylation (2010), Pulm. Pharmacol. Ther., 23, 36-42.

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Inhibitors

Inhibitors	Comment	Organism	Structure
N,N-dimethylsphingosine	decreases MUC5AC expression up-regulated by IL-13 treatment and inhibits IL-13-induced ERK1/2 phosphorylation but neither p38 MAPK nor STAT6 phosphorylation	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
epithelial cell	in airway epithelium of a mouse asthmatic model, both SphK and MUC5AC expression are increased and proteins co-localize	Mus musculus	-
epithelial cell	in bronchial epithelial cells, SphK1 and MUC5AC expression is increased by IL-13 treatment at both protein and mRNA levels, whereas SphK2 expression is not changed	Homo sapiens	-

Expression

Organism	Comment	Expression
Homo sapiens	in bronchial epithelial cells, SphK1 and MUC5AC expression is increased by IL-13 treatment at both protein and mRNA levels, whereas SphK2 expression is not changed. Inhibitor N,N-dimethylsphingosine decreases MUC5AC expression up-regulated by IL-13 treatment and inhibits IL-13-induced ERK1/2 phosphorylation but neither p38 MAPK nor STAT6 phosphorylation	up

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Release 2023.1 (January 2023)