Literature summary for 2.7.1.91 extracted from

Pushparaj, P.N.; Manikandan, J.; Tay, H.K.; Hng, S.C.; Kumar, S.D.; Pfeilschifter, J.; Huwiler, A.; Melendez, A.J.
Sphingosine kinase 1 is pivotal for Fc epsilon RI-mediated mast cell signaling and functional responses in vitro and in vivo (2009), J. Immunol., 183, 221-227.

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
mast cell	-	Mus musculus	-

General Information

General Information	Comment	Organism
physiological function	the knockdown of SphK1 by siRNA in mast cells inhibits several signaling mechanisms and effector functions, triggered by FcepsilonRI stimulation and including Ca2+ signals, NFkappaB activation, degranulation, cytokine/chemokine, and eicosanoid production. Silencing SphK2 has no effect at all. Silencing SPHK1 in vivo, in different strains of mice, strongly inhibits mast cell-mediated anaphylaxis, including inhibition of vascular permeability, tissue mast cell degranulation, changes in temperature, and serum histamine and cytokine levels, whereas silencing SPHK2 has no effect and the mice develop anaphylaxis. In mast cells derived from SPHK1-/- and SPHK2-/- mice, the calcium response and degranulation, triggered by FcepsilonRI-cross-linking, is not different from that triggered in wild-type cells. IgE-mediated anaphylaxis in the knockout mice shows similar levels in temperature changes and serum histamine to that from wild-type mice	Mus musculus

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Release 2023.1 (January 2023)