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BRENDA support

Literature summary for 2.7.1.91 extracted from

  • Ikeda, Y.; Ohashi, K.; Shibata, R.; Pimentel, D.R.; Kihara, S.; Ouchi, N.; Walsh, K.
    Cyclooxygenase-2 induction by adiponectin is regulated by a sphingosine kinase-1 dependent mechanism in cardiac myocytes (2008), FEBS Lett., 582, 1147-1150.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Source Tissue

Source Tissue Comment Organism Textmining
myocyte neonatal cardiac myocyte Rattus norvegicus
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General Information

General Information Comment Organism
physiological function adiponectin-induced COX-2 expression is reduced by treatment with a sphingosine kinase-1 inhibitor or siRNA targeting SphK-1. Treatment with a sphingosine-1-phosphate receptor antagonist also diminishes COX-2 expression in response to adiponectin stimulation Rattus norvegicus