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Literature summary for 2.7.1.91 extracted from

  • Kawamori, T.; Kaneshiro, T.; Okumura, M.; Maalouf, S.; Uflacker, A.; Bielawski, J.; Hannun, Y.A.; Obeid, L.M.
    Role for sphingosine kinase 1 in colon carcinogenesis (2009), FASEB J., 23, 405-414.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine 89% of human colon cancer samples tested stain positively for SphK1, whereas normal colon mucosa has negative or weak staining. Adenomas have higher expression of SphK1 versus normal mucosa, and colon cancers with metastasis have higher expression of SphK1 than those without metastasis Homo sapiens
medicine In the azoxymethane murine model of colon cancer, SphK1 and sphingosine 1-phosphate are significantly elevated in colon cancer tissues compared to normal mucosa. Blood levels of sphingosine 1-phosphate are higher in mice with colon cancers than in those without cancers. SphK1-/- mice subjected to azoxymethane have significantly less aberrant crypt foci formation and significantly reduced colon cancer development Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
colon
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Mus musculus
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colon
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Homo sapiens
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colonic cancer cell
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Mus musculus
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colonic cancer cell
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Homo sapiens
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General Information

General Information Comment Organism
physiological function SphK1-/- mice subjected to azoxymethane treatment have significantly less aberrant crypt foci formation and significantly reduced colon cancer development than wild-type Mus musculus