Literature summary for 2.7.1.91 extracted from

Li, W.; Yu, C.P.; Xia, J.T.; Zhang, L.; Weng, G.X.; Zheng, H.Q.; Kong, Q.L.; Hu, L.J.; Zeng, M.S.; Zeng, Y.X.; Li, M.; Li, J.; Song, L.B.
Sphingosine kinase 1 is associated with gastric cancer progression and poor survival of patients (2009), Clin. Cancer Res., 15, 1393-1399.

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Application

Application	Comment	Organism
medicine	levels of SPHK1mRNA and protein are higher in gastric cancer cell lines than in normal gastric epithelial cells. SPHK1 protein level is up-regulated in gastric cancer lesions compared with that in the paired adjacent noncancerous tissues. Gastric cancer tissues from 65.7% of patients reveals high level of SPHK1protein expression in contrast to the undetectable or marginally detectable expression of SPHK1 in the adjacent noncancerous gastric tissues. Significantly different expression levels of SPHK1 are found in patients at different clinical stages. Patients with higher SPHK1expression have shorter overall survival time, whereas those with lower SPHK1 expression survive longer	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
AGS cell	-	Homo sapiens	-
MGC-803 cell	-	Homo sapiens	-
MKN-28 cell	-	Homo sapiens	-
MKN-45 cell	-	Homo sapiens	-
SGC-7901 cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)