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Literature summary for 2.7.1.91 extracted from

  • Foss, F.W.; Mathews, T.P.; Kharel, Y.; Kennedy, P.C.; Snyder, A.H.; Davis, M.D.; Lynch, K.R.; Macdonald, T.L.
    Synthesis and biological evaluation of sphingosine kinase substrates as sphingosine-1-phosphate receptor prodrugs (2009), Bioorg. Med. Chem., 17, 6123-6136.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine synthesis of shingosine kinase substrates as sphingosine 1-phosphate receptor prodrugs, with varying activities at the five sphingosine 1-phosphate receptors Homo sapiens
medicine synthesis of shingosine kinase substrates as sphingosine 1-phosphate receptor prodrugs, with varying activities at the five sphingosine 1-phosphate receptors. Substrate (2R)-2-amino-2-[5-(4-octylphenyl)-1H-imidazol-2-yl]propan-1-ol causes lymphopenia for more than 20h Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + (2R)-2-amino-2-[5-(4-octylphenyl)-1H-imidazol-2-yl]propan-1-ol
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 Mus musculus ADP + (2R)-2-amino-2-[5-(4-octylphenyl)-1H-imidazol-2-yl]propyl dihydrogen phosphate product is a sphingosine 1-phosphate receptor prodrug ?
ATP + (2R)-2-amino-2-[5-(4-octylphenyl)-1H-imidazol-2-yl]propan-1-ol approximately 20% the activity of sphingosine at isoformSPHK2 Homo sapiens ADP + (2R)-2-amino-2-[5-(4-octylphenyl)-1H-imidazol-2-yl]propyl dihydrogen phosphate product is a sphingosine 1-phosphate receptor prodrug ?
ATP + 2-amino-2-[4-(4-octylphenyl)-1,3-oxazol-2-yl]propan-1-ol
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 Mus musculus ADP + 2-amino-2-[4-(4-octylphenyl)-1,3-oxazol-2-yl]propyl dihydrogen phosphate product is a sphingosine 1-phosphate receptor prodrug ?
ATP + 2-amino-2-[4-(4-octylphenyl)-1,3-oxazol-2-yl]propan-1-ol good substrate of isoform SPHK2 Homo sapiens ADP + 2-amino-2-[4-(4-octylphenyl)-1,3-oxazol-2-yl]propyl dihydrogen phosphate product is a sphingosine 1-phosphate receptor prodrug ?
ATP + 2-amino-2-[5-(4-octylphenyl)-1,2,4-oxadiazol-3-yl]propan-1-ol
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 Mus musculus ADP + 2-amino-2-[5-(4-octylphenyl)-1,2,4-oxadiazol-3-yl]propyl dihydrogen phosphate product is a sphingosine 1-phosphate receptor prodrug ?
ATP + 2-amino-2-[5-(4-octylphenyl)-1,2,4-oxadiazol-3-yl]propan-1-ol moderate activity at isoform SPHK2, it is the only alcohol in the series to have significant activity at isoform SPHK1 Homo sapiens ADP + 2-amino-2-[5-(4-octylphenyl)-1,2,4-oxadiazol-3-yl]propyl dihydrogen phosphate product is a sphingosine 1-phosphate receptor prodrug ?