Literature summary for 2.7.1.91 extracted from

Ter Braak, M.; Danneberg, K.; Lichte, K.; Liphardt, K.; Ktistakis, N.T.; Pitson, S.M.; Hla, T.; Jakobs, K.H.; Heringdorf, D.M.
Ga(q)-mediated plasma membrane translocation of sphingosine kinase-1 and cross-activation of S1P receptors (2009), Biochim. Biophys. Acta, 1791, 357-370.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression of isoform SphK1a in HEK-293 cell	Mus musculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
plasma membrane	activation of Gq protein-coupled receptors induces a profound, rapid and long-lasting translocation of isoform SphK1 to the plasma membrane	Mus musculus	5886	-

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	isoform SphK1a	-

General Information

General Information	Comment	Organism
physiological function	activation of Gq protein-coupled receptors induces a profound, rapid and long-lasting translocation of isoform SphK1 to the plasma membrane. Classical Gq signalling pathways, or phosphorylation at Ser225, phospholipase D and Ca2+/calmodulin are not involved in M3 receptor-induced SphK1 translocation in HEK-293 cells. Translocation is associated with Sphingosine 1-phosphate receptor internalization, which is dependent on catalytic activity of SphK1 and sphingosine 1-phosphate receptor binding and thus results from S1P receptor cross-activation	Mus musculus

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Release 2023.1 (January 2023)