Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.1.91 extracted from

  • Taha, T.A.; Hannun, Y.A.; Obeid, L.M.
    Sphingosine kinase: biochemical and cellular regulation and role in disease (2006), J. Biochem. Mol. Biol., 39, 113-131.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
cardiolipin
-
Homo sapiens
additional information not affected by bovine serum albumin Homo sapiens
additional information not stimulated by phosphatidylcholine or phosphatidylethanolamine Homo sapiens
phosphatidic acid
-
Homo sapiens
phosphatidylinositol
-
Homo sapiens
phosphatidylinositol bisphosphate
-
Homo sapiens
phosphatidylserine
-
Homo sapiens
Triton X-100
-
Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
bovine serum albumin
-
Homo sapiens
Cu2+
-
Homo sapiens
dimethylsphingosine noncompetitive inhibitor Homo sapiens
DL-threo-dihydrosphinganine competitive inhibitor Homo sapiens
DL-threo-dihydrosphingosine competitive inhibitor Homo sapiens
Fe2+
-
Homo sapiens
KCl increasing KCl concentration profoundly inhibits activity Homo sapiens
NaCl increasing NaCl concentration profoundly inhibits activity Homo sapiens
Triton X-100
-
Homo sapiens
Zn2+
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.005
-
sphingosine
-
Rattus norvegicus
0.0138
-
sphingosine
-
Homo sapiens
0.0156
-
sphingosine
-
Homo sapiens
0.07 0.1 ATP
-
Homo sapiens
0.093
-
ATP
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-
cytosol
-
Rattus norvegicus 5829
-
nucleus
-
Homo sapiens 5634
-
nucleus
-
Rattus norvegicus 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
K+ increasing KCl concentration stimulates activity Homo sapiens
Mg2+ highest activity in the presence of Mg2+ Homo sapiens
Mn2+
-
Homo sapiens
Na+ increasing NaCl concentration stimulates activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NRA0
-
-
Homo sapiens Q9NYA1
-
-
Rattus norvegicus Q91V26
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-
heart
-
Rattus norvegicus
-
kidney
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-
lung
-
Rattus norvegicus
-
platelet
-
Homo sapiens
-
spleen
-
Rattus norvegicus
-
thymus
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + DL-threo-dihydrosphingosine
-
Homo sapiens ADP + DL-threo-dihydrosphingosine 1-phosphate
-
?
ATP + FTY720
-
Homo sapiens ADP + ?
-
?
ATP + phytosphingosine
-
Homo sapiens ADP + phytosphingosine 1-phosphate
-
?
ATP + sphinganine
-
Homo sapiens ADP + sphinganine 1-phosphate
-
?
ATP + sphinganine SK2 has a higher substrate affinity to sphinganine than to sphingosine Homo sapiens ADP + sphinganine 1-phosphate
-
?
ATP + sphingosine
-
Homo sapiens ADP + sphingosine 1-phosphate
-
?
ATP + sphingosine
-
Rattus norvegicus ADP + sphingosine 1-phosphate
-
?
additional information shows no activity towards DL-threo-dihydrosphingosine, dimethylsphingosine, C2-ceramide, dioleoylacylglycerol, or phosphatidylserine Homo sapiens ?
-
?
additional information shows no activity towards DL-threo-dihydrosphingosine, dimethylsphingosine, C2-ceramide, dioleoylacylglycerol, or phosphatidylserine Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
SK1
-
Homo sapiens
SK1
-
Rattus norvegicus
SK2
-
Homo sapiens
sphinganine kinase
-
Homo sapiens
sphinganine kinase
-
Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
-
Homo sapiens
7.4
-
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens
ATP
-
Rattus norvegicus