Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cardiolipin | - |
Homo sapiens | |
additional information | not affected by bovine serum albumin | Homo sapiens | |
additional information | not stimulated by phosphatidylcholine or phosphatidylethanolamine | Homo sapiens | |
phosphatidic acid | - |
Homo sapiens | |
phosphatidylinositol | - |
Homo sapiens | |
phosphatidylinositol bisphosphate | - |
Homo sapiens | |
phosphatidylserine | - |
Homo sapiens | |
Triton X-100 | - |
Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
bovine serum albumin | - |
Homo sapiens | |
Cu2+ | - |
Homo sapiens | |
dimethylsphingosine | noncompetitive inhibitor | Homo sapiens | |
DL-threo-dihydrosphinganine | competitive inhibitor | Homo sapiens | |
DL-threo-dihydrosphingosine | competitive inhibitor | Homo sapiens | |
Fe2+ | - |
Homo sapiens | |
KCl | increasing KCl concentration profoundly inhibits activity | Homo sapiens | |
NaCl | increasing NaCl concentration profoundly inhibits activity | Homo sapiens | |
Triton X-100 | - |
Homo sapiens | |
Zn2+ | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.005 | - |
sphingosine | - |
Rattus norvegicus | |
0.0138 | - |
sphingosine | - |
Homo sapiens | |
0.0156 | - |
sphingosine | - |
Homo sapiens | |
0.07 | 0.1 | ATP | - |
Homo sapiens | |
0.093 | - |
ATP | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
cytosol | - |
Rattus norvegicus | 5829 | - |
nucleus | - |
Homo sapiens | 5634 | - |
nucleus | - |
Rattus norvegicus | 5634 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
K+ | increasing KCl concentration stimulates activity | Homo sapiens | |
Mg2+ | highest activity in the presence of Mg2+ | Homo sapiens | |
Mn2+ | - |
Homo sapiens | |
Na+ | increasing NaCl concentration stimulates activity | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9NRA0 | - |
- |
Homo sapiens | Q9NYA1 | - |
- |
Rattus norvegicus | Q91V26 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
heart | - |
Rattus norvegicus | - |
kidney | - |
Rattus norvegicus | - |
liver | - |
Rattus norvegicus | - |
lung | - |
Rattus norvegicus | - |
platelet | - |
Homo sapiens | - |
spleen | - |
Rattus norvegicus | - |
thymus | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + DL-threo-dihydrosphingosine | - |
Homo sapiens | ADP + DL-threo-dihydrosphingosine 1-phosphate | - |
? | |
ATP + FTY720 | - |
Homo sapiens | ADP + ? | - |
? | |
ATP + phytosphingosine | - |
Homo sapiens | ADP + phytosphingosine 1-phosphate | - |
? | |
ATP + sphinganine | - |
Homo sapiens | ADP + sphinganine 1-phosphate | - |
? | |
ATP + sphinganine | SK2 has a higher substrate affinity to sphinganine than to sphingosine | Homo sapiens | ADP + sphinganine 1-phosphate | - |
? | |
ATP + sphingosine | - |
Homo sapiens | ADP + sphingosine 1-phosphate | - |
? | |
ATP + sphingosine | - |
Rattus norvegicus | ADP + sphingosine 1-phosphate | - |
? | |
additional information | shows no activity towards DL-threo-dihydrosphingosine, dimethylsphingosine, C2-ceramide, dioleoylacylglycerol, or phosphatidylserine | Homo sapiens | ? | - |
? | |
additional information | shows no activity towards DL-threo-dihydrosphingosine, dimethylsphingosine, C2-ceramide, dioleoylacylglycerol, or phosphatidylserine | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SK1 | - |
Homo sapiens |
SK1 | - |
Rattus norvegicus |
SK2 | - |
Homo sapiens |
sphinganine kinase | - |
Homo sapiens |
sphinganine kinase | - |
Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
- |
Homo sapiens |
7.4 | - |
- |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens | |
ATP | - |
Rattus norvegicus |