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Literature summary for 2.7.1.91 extracted from
- Prolactin upregulates sphingosine kinase-1 expression and activity in the human breast cancer cell line MCF7 and triggers enhanced proliferation and migration (2007), Endocr. Relat. Cancer, 14, 325-335.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | not activated by prolactin | Homo sapiens | |
| prolactin | - |
Homo sapiens |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | anti-tumor therapy | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9NRA0 | - |
- |
| Homo sapiens | Q9NYA1 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| MCF-7 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + sphingosine | - |
Homo sapiens | ADP + sphingosine 1-phosphate | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SK-1 | - |
Homo sapiens |
| SK-2 | - |
Homo sapiens |
| sphinganine kinase | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
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