Cloned (Comment) | Organism |
---|---|
gene Sk1, DNA and amino acid sequence determination and analysis, 2 splicing variants, location on the X chromosome, functional overexpression of Sk1 in the yeast strain JSK398 | Drosophila melanogaster |
gene Sk2, DNA and amino acid sequence determination and analysis, a single intron, location on chromosome 3, functional overexpression of Sk2 in the yeast strain JSK398 | Drosophila melanogaster |
Protein Variants | Comment | Organism |
---|---|---|
additional information | complementation of yeast enzyme-deficient mutant strain by both Sk1 and Sk2 | Drosophila melanogaster |
additional information | complementation of yeast enzyme-deficient mutant strain by both Sk1 and Sk2, a Drosophila melanogaster null Sk2 transposon insertion mutant shows elevated long chain base levels, impaired flight performance, and diminished ovulation, phenotype analysis | Drosophila melanogaster |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | isozymes Sk1 and Sk2, predominantly | Drosophila melanogaster | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + dihydrosphingosine | Drosophila melanogaster | C14 and C16 dihydrosphingosine substrates | ADP + dihydrosphingosine 1-phosphate | - |
? | |
ATP + sphingosine | Drosophila melanogaster | C14 and C16 sphingosine substrates | ADP + sphingosine 1-phosphate | - |
? | |
additional information | Drosophila melanogaster | requirement for Sk2 in normal reproductive function, product S1P signaling promotes cell proliferation, survival, and migration, enzyme reduces cellular levels of sphingosine and ceramide, sphingolipid metabolism, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | Q9VYY8 | isozyme Sk1; 2 isozymes Sk1 and Sk2 encoded by 2 genes Sk1 and Sk2 | - |
Drosophila melanogaster | Q9VZW0 | isozyme Sk2; 2 isozymes Sk1 and Sk2 encoded by 2 genes Sk1 and Sk2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryo | expression pattern of Sk1 during embryogenesis | Drosophila melanogaster | - |
embryo | expression pattern of Sk2 during embryogenesis | Drosophila melanogaster | - |
additional information | the 2 genes Sk1 and Sk2 show overlapping but distinct temporal and spatial expression patterns | Drosophila melanogaster | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + dihydrosphingosine | - |
Drosophila melanogaster | ADP + dihydrosphingosine 1-phosphate | - |
? | |
ATP + dihydrosphingosine | C14 and C16 dihydrosphingosine substrates | Drosophila melanogaster | ADP + dihydrosphingosine 1-phosphate | - |
? | |
ATP + sphingosine | - |
Drosophila melanogaster | ADP + sphingosine 1-phosphate | - |
? | |
ATP + sphingosine | C14 and C16 sphingosine substrates | Drosophila melanogaster | ADP + sphingosine 1-phosphate | - |
? | |
additional information | requirement for Sk2 in normal reproductive function, product S1P signaling promotes cell proliferation, survival, and migration, enzyme reduces cellular levels of sphingosine and ceramide, sphingolipid metabolism, overview | Drosophila melanogaster | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SK | - |
Drosophila melanogaster |
sphinganine kinase | - |
Drosophila melanogaster |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Drosophila melanogaster |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.2 | - |
assay at | Drosophila melanogaster |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Drosophila melanogaster |