Cloned (Comment) | Organism |
---|---|
overexpression of gene sgkA leads to increased resistance to the anticancer drug cisplatin and altered growth behaviour | Dictyostelium discoideum |
Protein Variants | Comment | Organism |
---|---|---|
additional information | disruption mutants of genes sgkA and sgkB, single mutants with reduced activity, or double mutants nearly inactive, show increased sensitivity to the anticancer drug cisplatin and altered growth behaviour | Dictyostelium discoideum |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Dictyostelium discoideum | 5829 | - |
nucleus | - |
Dictyostelium discoideum | 5634 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Dictyostelium discoideum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + sphingosine | Dictyostelium discoideum | - |
ADP + sphingosine 1-phosphate | - |
? | |
additional information | Dictyostelium discoideum | sphingosine 1-phosphate is responsible for resistance to the anticancer drug cisplatin | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Dictyostelium discoideum | - |
isozymes SgkA and SgkB encoded by the genes sgkA and sgkB | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
pseudopodium | - |
Dictyostelium discoideum | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
activity of mutant strains | Dictyostelium discoideum |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + sphingosine | - |
Dictyostelium discoideum | ADP + sphingosine 1-phosphate | - |
? | |
additional information | sphingosine 1-phosphate is responsible for resistance to the anticancer drug cisplatin | Dictyostelium discoideum | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SGK | - |
Dictyostelium discoideum |
sphinganine kinase | - |
Dictyostelium discoideum |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
28 | - |
assay at | Dictyostelium discoideum |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Dictyostelium discoideum |