Cloned (Comment) | Organism |
---|---|
- |
Drosophila melanogaster |
- |
Saccharomyces cerevisiae |
- |
Tetrahymena pyriformis |
- |
Arabidopsis thaliana |
- |
Caenorhabditis elegans |
DNA and amino acid sequence determination and analysis | Mus musculus |
DNA and amino acid sequence determination and analysis | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
DL-threo-dihydrosphingosine | - |
Homo sapiens | |
DL-threo-dihydrosphingosine | - |
Mus musculus | |
N,N-dimethylsphingosine | - |
Homo sapiens | |
N,N-dimethylsphingosine | - |
Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Mus musculus | 5829 | - |
cytosol | - |
Homo sapiens | 5829 | - |
extracellular | - |
Mus musculus | - |
- |
extracellular | - |
Homo sapiens | - |
- |
additional information | subcellular localization depends on the tissue type | Mus musculus | - |
- |
additional information | subcellular localization depends on the tissue type | Homo sapiens | - |
- |
nucleus | - |
Mus musculus | 5634 | - |
nucleus | - |
Homo sapiens | 5634 | - |
plasma membrane | - |
Mus musculus | 5886 | - |
plasma membrane | - |
Homo sapiens | 5886 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + D-erythro-sphingosine | Mus musculus | - |
ADP + D-erythro-sphingosine 1-phosphate | - |
ir | |
ATP + D-erythro-sphingosine | Homo sapiens | - |
ADP + D-erythro-sphingosine 1-phosphate | - |
ir | |
ATP + phytosphingosine | Mus musculus | - |
ADP + phytosphingosine 1-phosphate | - |
ir | |
ATP + phytosphingosine | Homo sapiens | - |
ADP + phytosphingosine 1-phosphate | - |
ir | |
ATP + sphinganine | Mus musculus | - |
ADP + sphinganine 1-phosphate | - |
? | |
ATP + sphinganine | Homo sapiens | - |
ADP + sphinganine 1-phosphate | - |
? | |
ATP + sphingosine | Drosophila melanogaster | - |
ADP + sphingosine 1-phosphate | sphingosine 1-phosphate is a potent bioactive sphingolipid, sphingolipid metabolism, overview | ir | |
ATP + sphingosine | Mus musculus | - |
ADP + sphingosine 1-phosphate | sphingosine 1-phosphate is a potent bioactive sphingolipid, sphingolipid metabolism, overview | ir | |
ATP + sphingosine | Homo sapiens | - |
ADP + sphingosine 1-phosphate | sphingosine 1-phosphate is a potent bioactive sphingolipid, sphingolipid metabolism, overview | ir | |
ATP + sphingosine | Saccharomyces cerevisiae | - |
ADP + sphingosine 1-phosphate | sphingosine 1-phosphate is a potent bioactive sphingolipid, sphingolipid metabolism, overview | ir | |
ATP + sphingosine | Tetrahymena pyriformis | - |
ADP + sphingosine 1-phosphate | sphingosine 1-phosphate is a potent bioactive sphingolipid, sphingolipid metabolism, overview | ir | |
ATP + sphingosine | Arabidopsis thaliana | - |
ADP + sphingosine 1-phosphate | sphingosine 1-phosphate is a potent bioactive sphingolipid, sphingolipid metabolism, overview | ir | |
ATP + sphingosine | Caenorhabditis elegans | - |
ADP + sphingosine 1-phosphate | sphingosine 1-phosphate is a potent bioactive sphingolipid, sphingolipid metabolism, overview | ir | |
additional information | Homo sapiens | the enzyme is involved in many cellular processes, e.g. mast cell activation during inflammation, immunoactivation via intracellular Ca2+ and receptor activation and via neutrophil, macrophage, and monocyte activation, angiogenesis and control of cell adhesion molecule expression, anti-apoptosis, chemotaxis of leukocytes | ? | - |
? | |
additional information | Mus musculus | the enzyme is involved in many cellular processes, e.g. mast cell activation during inflammation, immunoactivation via intracellular Ca2+ and receptor activation, angiogenesis and control of cell adhesion molecule expression, anti-apoptosis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Arabidopsis thaliana | - |
- |
- |
Caenorhabditis elegans | - |
- |
- |
Drosophila melanogaster | - |
- |
- |
Homo sapiens | - |
2 isozymes SPHK1 and SPHK2 | - |
Mus musculus | - |
2 isozymes SPHK1 and SPHK2 | - |
Saccharomyces cerevisiae | - |
- |
- |
Tetrahymena pyriformis | - |
- |
- |
Purification (Comment) | Organism |
---|---|
isozyme SPHK1 | Mus musculus |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
ATP + a sphingoid base = ADP + a sphingoid base 1-phosphate | catalytic mechanism | Drosophila melanogaster | |
ATP + a sphingoid base = ADP + a sphingoid base 1-phosphate | catalytic mechanism | Saccharomyces cerevisiae | |
ATP + a sphingoid base = ADP + a sphingoid base 1-phosphate | catalytic mechanism | Tetrahymena pyriformis | |
ATP + a sphingoid base = ADP + a sphingoid base 1-phosphate | catalytic mechanism | Arabidopsis thaliana | |
ATP + a sphingoid base = ADP + a sphingoid base 1-phosphate | catalytic mechanism | Caenorhabditis elegans | |
ATP + a sphingoid base = ADP + a sphingoid base 1-phosphate | catalytic mechanism, the catalytic domain contains the C1-C5 sequence stretches and the ATP-binding site | Mus musculus | |
ATP + a sphingoid base = ADP + a sphingoid base 1-phosphate | catalytic mechanism, the catalytic domain contains the C1-C5 sequence stretches and the ATP-binding site | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood platelet | - |
Mus musculus | - |
blood platelet | - |
Homo sapiens | - |
brain | white matter, cerebellum, cerebrum, red nucleus, cerebral peduncle | Mus musculus | - |
brain | white matter, cerebellum, cerebrum, red nucleus, cerebral peduncle | Homo sapiens | - |
cerebellum | - |
Mus musculus | - |
cerebellum | - |
Homo sapiens | - |
cerebrum | - |
Mus musculus | - |
cerebrum | - |
Homo sapiens | - |
endothelium | - |
Mus musculus | - |
endothelium | - |
Homo sapiens | - |
heart | - |
Mus musculus | - |
heart | - |
Homo sapiens | - |
kidney | - |
Mus musculus | - |
kidney | - |
Homo sapiens | - |
leukocyte | of peripheral blood | Mus musculus | - |
leukocyte | of peripheral blood | Homo sapiens | - |
liver | - |
Mus musculus | - |
liver | - |
Homo sapiens | - |
lung | - |
Mus musculus | - |
lung | - |
Homo sapiens | - |
megacaryocyte | - |
Homo sapiens | - |
megakaryocyte | - |
Mus musculus | - |
additional information | isozyme tissue distribution | Mus musculus | - |
additional information | isozyme tissue distribution | Homo sapiens | - |
neutrophil | - |
Homo sapiens | - |
spleen | - |
Mus musculus | - |
spleen | - |
Homo sapiens | - |
thymus | - |
Mus musculus | - |
thymus | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + D-erythro-sphingosine | - |
Mus musculus | ADP + D-erythro-sphingosine 1-phosphate | - |
ir | |
ATP + D-erythro-sphingosine | - |
Homo sapiens | ADP + D-erythro-sphingosine 1-phosphate | - |
ir | |
ATP + phytosphingosine | - |
Mus musculus | ADP + phytosphingosine 1-phosphate | - |
ir | |
ATP + phytosphingosine | - |
Homo sapiens | ADP + phytosphingosine 1-phosphate | - |
ir | |
ATP + sphinganine | - |
Mus musculus | ADP + sphinganine 1-phosphate | - |
? | |
ATP + sphinganine | - |
Homo sapiens | ADP + sphinganine 1-phosphate | - |
? | |
ATP + sphingosine | - |
Drosophila melanogaster | ADP + sphingosine 1-phosphate | - |
ir | |
ATP + sphingosine | - |
Mus musculus | ADP + sphingosine 1-phosphate | - |
ir | |
ATP + sphingosine | - |
Homo sapiens | ADP + sphingosine 1-phosphate | - |
ir | |
ATP + sphingosine | - |
Saccharomyces cerevisiae | ADP + sphingosine 1-phosphate | - |
ir | |
ATP + sphingosine | - |
Tetrahymena pyriformis | ADP + sphingosine 1-phosphate | - |
ir | |
ATP + sphingosine | - |
Arabidopsis thaliana | ADP + sphingosine 1-phosphate | - |
ir | |
ATP + sphingosine | - |
Caenorhabditis elegans | ADP + sphingosine 1-phosphate | - |
ir | |
ATP + sphingosine | - |
Drosophila melanogaster | ADP + sphingosine 1-phosphate | sphingosine 1-phosphate is a potent bioactive sphingolipid, sphingolipid metabolism, overview | ir | |
ATP + sphingosine | - |
Mus musculus | ADP + sphingosine 1-phosphate | sphingosine 1-phosphate is a potent bioactive sphingolipid, sphingolipid metabolism, overview | ir | |
ATP + sphingosine | - |
Homo sapiens | ADP + sphingosine 1-phosphate | sphingosine 1-phosphate is a potent bioactive sphingolipid, sphingolipid metabolism, overview | ir | |
ATP + sphingosine | - |
Saccharomyces cerevisiae | ADP + sphingosine 1-phosphate | sphingosine 1-phosphate is a potent bioactive sphingolipid, sphingolipid metabolism, overview | ir | |
ATP + sphingosine | - |
Tetrahymena pyriformis | ADP + sphingosine 1-phosphate | sphingosine 1-phosphate is a potent bioactive sphingolipid, sphingolipid metabolism, overview | ir | |
ATP + sphingosine | - |
Arabidopsis thaliana | ADP + sphingosine 1-phosphate | sphingosine 1-phosphate is a potent bioactive sphingolipid, sphingolipid metabolism, overview | ir | |
ATP + sphingosine | - |
Caenorhabditis elegans | ADP + sphingosine 1-phosphate | sphingosine 1-phosphate is a potent bioactive sphingolipid, sphingolipid metabolism, overview | ir | |
additional information | the enzyme is involved in many cellular processes, e.g. mast cell activation during inflammation, immunoactivation via intracellular Ca2+ and receptor activation and via neutrophil, macrophage, and monocyte activation, angiogenesis and control of cell adhesion molecule expression, anti-apoptosis, chemotaxis of leukocytes | Homo sapiens | ? | - |
? | |
additional information | the enzyme is involved in many cellular processes, e.g. mast cell activation during inflammation, immunoactivation via intracellular Ca2+ and receptor activation, angiogenesis and control of cell adhesion molecule expression, anti-apoptosis | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
sphinganine kinase | - |
Drosophila melanogaster |
sphinganine kinase | - |
Mus musculus |
sphinganine kinase | - |
Homo sapiens |
sphinganine kinase | - |
Saccharomyces cerevisiae |
sphinganine kinase | - |
Tetrahymena pyriformis |
sphinganine kinase | - |
Arabidopsis thaliana |
sphinganine kinase | - |
Caenorhabditis elegans |
SPHK | - |
Drosophila melanogaster |
SPHK | - |
Mus musculus |
SPHK | - |
Homo sapiens |
SPHK | - |
Saccharomyces cerevisiae |
SPHK | - |
Tetrahymena pyriformis |
SPHK | - |
Arabidopsis thaliana |
SPHK | - |
Caenorhabditis elegans |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Drosophila melanogaster | |
ATP | - |
Mus musculus | |
ATP | - |
Homo sapiens | |
ATP | - |
Saccharomyces cerevisiae | |
ATP | - |
Tetrahymena pyriformis | |
ATP | - |
Arabidopsis thaliana | |
ATP | - |
Caenorhabditis elegans |