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Literature summary for 2.7.1.91 extracted from

  • Stoffel, W.; Hellenbroich, B.; Heimann, G.
    Properties and specificities of sphingosine kinase from blood platelets (1973), Hoppe-Seyler's Z. Physiol. Chem., 354, 1311-1316.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
D(+)threo-Sphinganine
-
Homo sapiens
EDTA
-
Homo sapiens
L(-)erythro-Sphinganine
-
Homo sapiens
L(-)threo-Sphinganine
-
Homo sapiens
N-ethylmaleimide
-
Homo sapiens
p-chloromercuribenzoate
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.072
-
D-(+)-erythro-sphinganine
-
Homo sapiens
1
-
L-(-)-threo-sphinganine
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Homo sapiens 5737
-
cytoplasm
-
Sus scrofa 5737
-
soluble
-
Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ stimulation at concentration equimolar to ATP Homo sapiens
Mn2+ stimulation at concentration equimolar to ATP Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
thrombocyte
-
Homo sapiens
-
thrombocyte
-
Sus scrofa
-

Storage Stability

Storage Stability Organism
-18°C, stable for at least 3 weeks Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + D-(+)-erythro-sphinganine
-
Homo sapiens ADP + D-(+)-erythro-sphinganine 1-phosphate
-
?
ATP + L-(-)-threo-sphinganine
-
Homo sapiens ADP + L-(-)-threo-sphinganine 1-phosphate
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
-
Homo sapiens
7
-
-
Sus scrofa

pH Range

pH Minimum pH Maximum Comment Organism
6 8.5 pH 6: about 55% of maximum activity, pH 8.5: about 40% of maximum activity Homo sapiens